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The reward circuit and related structures may participate in the interactions between the GLP-1 pathway and psychoactive substances, as GLP-1Rs are expressed in key brain regions like the ventral tegmental area (VTA) and the nucleus accumbens (NAc) that control reward behaviors [54]

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On April 30, 2026, the FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B compounding bulks list, citing no clinical need for outsourcing facilities to compound these drugs from bulk substances