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Her plan includes: Adjusting her GLP-1 dose and aiming for a steadier rate of loss

Furthermore, this novel concept suggests that the GLP-1 analog could spare the pasireotide-induced decrease in endogenous GLP-1 concentrations and recover insulin secretion suppressed by pasireotide through GLP-1R-Gs activation counteracting the SSTRs-Gi axis

GLP-1 RAs do not increase cancer risk in patients with T2DM

This might involve a washout period (letting the first drug clear almost completely) or a carefully planned overlap, all based on the half-lives of the medications involved

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Delayed gastric emptying extends satiety signals, though this effect diminishes somewhat over time through natural adaptation