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Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism
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MUC2, a core barrier component and key regulatory target, is suppressed under dual inhibition by ischemia-activated HIF-1 and TNF--mediated NF-B signaling, which decreases MUC2 promoter activity and hinders its transcription/expression in intestinal epithelial cells (Liu et al., 2023)
The case report literature on GLP-1 agonists and anorgasmia identifies decreased norepinephrine signaling as a potential contributor to orgasmic dysfunction, which represents a separate but related concern from decreased desire
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