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The interaction between iron regulatory elements ( IREs ) and iron regulatory proteins ( IRPs ) ensures that iron is appropriately utilized and stored, further connecting heme metabolism with iron recycling [21, 22]

Typically, when one of these subsets is activated, the other is inhibited

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Unfortunately, bupropion is a bit of a lone wolf in the antidepressant world, as it's the only norepinephrine-dopamine reuptake inhibitor (NDRI) currently sold on the market (per WebMD), so options that act similarly to Wellbutrin in the body are limited

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Mouchiroud, L., Houtkooper, R