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In a pooled analysis of clinical trials assessing patients with heart failure with preserved ejection fraction (HFpEF), including the STEP HFpEF and STEP HFpEF DM trials, as well as in the FLOW and SELECT trials, semaglutide improved New York Heart Association (NYHA) class IIIV symptoms, physical limitations, exercise function, associated with a 30% reduction of N-terminal pro-brain natriuretic peptide and a 31% reduction in the composite endpoint of cardiovascular death and the need for treatment intensification or hospitalization for heart failure-related events (HR 0.69
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The table includes mean weight-loss percentage, approximate absolute weight loss (pounds), trial duration and the trial name
This frugality extends to manufacturing generics as India has historically been a "generic powerhouse"
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