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Xiong, A

GLP-1 Receptor Agonists May Modestly Reduce Risk of Fourteen Obesity-Related Cancers for People With Diabetes

Glu9 of the GLP-1 forms a direct hydrogen bond with Tyr152, an ionic interactions with Arg190, and a water mediated hydrogen bond with Tyr241

Lab-produced GLP-1 drugs remain active for a very long time (whereas GLP-1 produced by the body decomposes in a few minutes), which means that patients can be treated with a weekly injection

They also act on the digestive system to delay gastric emptying, delaying the release of food from the stomach and modulating brain activity to suppress appetite

Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss