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Abstract There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids

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Very dark brown urine, especially when it occurs with yellowing of the skin or eyes, can suggest a liver problem

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More serious but less common adverse effects include pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in animal studies, though the clinical relevance in humans remains uncertain)