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The cases of brain disorders by 2050 are projected to have a 22% increase from 2021 estimates, with the most prevalent conditions being migraine, Alzheimers disease, depressive and anxiety disorders, and strokes (Lei and Gillespie, 2024)

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Most of the genes able to reduce the risk against certain infections as the malaria are expressed in the red blood cell, which is considered like a genetic and/or evolutionary mechanism of defense, as in the case of the genes that express the G6PD 21