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MOTS-c treatment significantly (i) improves physical performance in young, middle-age, and old mice, (ii) regulates skeletal muscle metabolism and gene expression, and (iii) enhances adaptation to metabolic stress in C2C12 cells in an HSF1-dependent manner

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3b, c), while no significant differences in caloric intake were noted between the groups (Fig

Because PWS primarily affects the brain, intranasal delivery provides a shortcut to the central nervous system while reducing systemic exposure and side effects

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excursions permitted to 59F to 86F