[1] It is important to understand that FDA-approved tirzepatide is supplied as a pre-filled, single-dose pen containing a sterile solution ready for injection
Management of MetS risk factors The metabolic risk variables in the syndromes definition include atherogenic dyslipidemia, elevated blood pressure, high plasma glucose, a prothrombotic condition, and a pro-inflammatory state (45)
Available from: NICE [Internet]
Possible adverse effects may include: Injection site reactions : Redness, swelling, irritation, or discomfort Gastrointestinal symptoms : Nausea, vomiting, stomach cramps, or diarrhea Headaches or dizziness Allergic reactions : Rash, itching, shortness of breath, or facial swelling (rare) Increased heart rate or anxiety (typically temporary from B-vitamins) Fatigue or weakness if used improperly Elevated liver enzymes when taken in excess particularly with methionine or choline Insomnia if taken late in the day due to increased energy levels Who should avoid or use caution
Guo, H., Zhang, L., Wang, Y
Rebound weight gain is a real risk, but with slow tapering, structured lifestyle changes, and a supportive care team, it can be minimised