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Retatrutide binds to receptors involved in reducing the desire for food

Nausea is one of the most frequently reported side effects associated with retatrutide in clinical trials to date, as documented in the Phase 2 randomised controlled trial published in the New England Journal of Medicine in June 2023 (Jastreboff et al., NEJM 2023)

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For a long time, the idea of activating the glucagon receptor seemed counterintuitive for metabolic control, as glucagon's primary role is to raise blood sugar by telling the liver to release glucose