(Summarized from Czimmerer et al., 2023
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It has been shown that VitC selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH [32], which may also explain why VitC shows to be especially promising in the treatment of pancreatic cancer, where over 90% of the cases harbour KRAS mutations [260] and MM, where RAS family genes also show the most frequent mutations [113]
10.1080/19490976.2023.2271613 143 ZhangZ.JiangC.XingY
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How Non-Conjugation Fits Into The Detox Pipeline The full detoxification sequence runs through three phases, and non-conjugation reactions occupy a critical middle position