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Ozempic, Wegovy, Mounjaro, and similar medications cause significant fat mobilization through both caloric restriction and metabolic changes

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These convergent effects support the hypothesis that multi-incretin agonists may exert central benefits beyond metabolic regulation

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Journal of Biological Chemistry, 268 (4), 25712576

Factors accelerating tolerance include consistent calorie restriction without adequate protein, insufficient water intake, sedentary behavior, and rapid dose escalation followed by long plateaus at a single dose