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or high-throughput assay designs where vial-to-vial batch variation would introduce unacceptable experimental noise

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In non-pregnant populations, several inflammatory disease conditions have been tightly linked to mitochondrial dysfunction, in large part driven by profound overactivity of NAD + -consuming enzymes, leading to depletion of intracellular NAD + (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)