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Why Weight Loss Plateaus on Semaglutide or Tirzepatide and What to Do About It Joshua Silva, MD Dec 16, 2025 6 min read Updated: Jan 15 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Many people taking semaglutide or tirzepatide notice that weight loss is faster at first and then slows or pauses over time

Wegovy is FDA-approved for chronic weight management and cardiovascular risk reductionnot diabetes

People are saying it is like metformin, but it is not, said Dr

This arrangement would produce savings for individuals who take drugs with high rebates, since they would face lower out-of-pocket costs on their medications when they fill their prescriptions

Understanding these pathways can inform provider discussions about titration speed and dose-adjustment expectations

Regarding drug interactions , while Saxenda may delay the absorption of oral medications due to slowed gastric emptying, clinically significant interactions are uncommon according to the SmPC