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Unlike myotubes formed during embryonic development, cultured myotubes do not mature into myofibres

When it is rapid, it may not have sufficient time

it should not be used by anyone with a personal or family history of medullary thyroid carcinoma or MEN 2

The detrimental effects of ROS on cartilage homeostasis can be effectively alleviated by augmenting cellular antioxidant activity under stress conditions, and several attempts have been made to treat OA by targeting the regulators involved in oxidative stress production in cartilage 84,85,86

Further randomized controlled trials are needed to confirm these results

In addition, the development cycles are long and the success rate is low, which are critical factors restricting drug development