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Therefore, a higher dietary glycemic load appears related with elevated fasting glucose levels, hyperinsulinemia and IR, that are responsible for a higher release of free IGF-I and androgens ultimately resulting in endocrine disturbance and oocyte maturative defects (45)

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Virus-induced hypoxia/Warburg effect SARS-CoV-2 hijacks host cellular metabolic machinery to extract adequate energy and carbon skeletons to facilitate viral entry and facilitate molecular constructions for viral progeny inside a host cell for replication and propagation

These findings suggest that moderate hypoxic preconditioning does not globally enhance USC-derived trophic factor secretion, but instead induces a more selective, VEGF-dominant pro-angiogenic secretory response

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