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The compounded GLP-1 market changes rapidly as regulatory pressures and legal challenges reshape the industry

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This was patented by Novo Nordisk in 1996 and the first paper on it was published in 2000 (Knudsen, Nielsen, Huusfeldt)

aleniglipron and orforglipron) are functionally Gs-biased and recruit -arrestin poorly (which is typically involved in turning off the GLP-1 receptor's signal by promoting internalization and downregulation and mediating nausea and vomiting)

However, the medications also have significant side effects, including unintended muscle mass loss, nutritional deficiencies, a potential for increased risk of miscarriage or birth defects, and severe mental health issues like depression and suicidal thoughts

As always, talk to your doctor before taking any medications