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After subcutaneous injection, it reaches peak plasma concentration within 5 to 20 minutes and is rapidly cleaved by dipeptidyl peptidase IV (DPP-IV) and other serum endopeptidases [2]

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In this regard, the first dual modulator 7 was published in 2017 by Schmidt et al., 2017 Following a combinatorial approach, the authors merged the structures of a previously reported sEH inhibitor (Kompa et al., 2013) with an selective FXR partial agonist (Merk et al., 2014b)