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Second, there is no long-term human dosing data, so nobody can tell you what a year of use does

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The incidence of nausea and diarrhea was higher with combination therapy versus SGLT-2i monotherapy (MD = 3.34, 95% CI 1.74

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The patient started taking Friday injections on Thursday for convenience, then Wednesday when Thursday was busy, and eventually settled into a de facto 5- to 6-day cycle without recognizing the pattern