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They do not differ in the fundamental constraint: molecules above roughly 500 daltons don't cross intact stratum corneum passively, and the botanicals that do fit under that threshold arrive at doses two to three orders of magnitude below anything studied

Freudlsperger C, Bian Y, Contag WS, Burnett J, Coupar J, Yang X, et al

93 Impaired SIRT1 function decreases PPAR activity, leading to lipid metabolism disorders, increased hepatic lipid deposition, and aggravated inflammatory responses

Bioinformatics 2020

Track and follow up for adherence, AE reporting, and adjustments