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There are a number of things that could be going on and explain the deterioriation in mood - some people don't respond well to methyl - some people need much higher levels of B12 post loading shots - potentially much higher than the normal or even measurable range

This absence of foundational pharmacokinetic information constitutes a major knowledge gap with direct implications for clinical application, dosing strategies, and safety monitoring

10.2217/nmt-2018-0013 311 ZhangJ.ZhouX.WuW.WangJ.XieH.WuZ

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Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ et al (2012) Diversity of bifidobacteria within the infant gut microbiota