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Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans

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The receptor itself is encoded by the GLP1R gene, and natural variation in that gene is one reason responses differ from person to person, something we map in the GLP-1 and metabolic pathway in your genetics report

Semaglutide has been approved by the FDA for therapeutic use and is also widely used in research studies

GLP-1s also appear to directly lower the amount of fat stored in liver cells, though the exact mechanism is not clearly understood