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In the pivotal 64-week trial of oral semaglutide 25 mg (the Wegovy tablet), participants had substantially greater average weight reduction than placebo, as reported in PubMed and summarized by the American College of Cardiology

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Oral semaglutide may be preferred by those looking to avoid needles, while injectable semaglutide offers stronger results and a more flexible dosing schedule

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Safety Considerations and Monitoring in Adolescents Adolescent use of GLP-1 therapy requires more frequent clinical monitoring than adult treatment