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doi:10.1351/pac199365061113

12 weeks on, 8-12 weeks off: Extended cycles with equivalent rest periods

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Non-obese individuals often seek these medications for improved body composition, reduced visceral fat accumulation, better glycemic control, or cardiovascular risk factor modification

[1] Unlike the folic acid derivative leucovorin, folic acid is not clinically useful in offsetting the action of folate reductase inhibitors because it requires the enzyme dihydrofolate reductase for activation