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nonfibrotic diabetic kidney ANGPTL4 is a known inhibitor of LPL, an enzyme that catalyzes the hydrolysis of triglycerides into fatty acids, which are used by peripheral tissues and kidney tubules (Kersten, 2021

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This reversal of the LDH reaction in hepatocytes diverts pyruvate from gluconeogenesis leading to a reduction in the capacity of the liver to deliver glucose to the blood

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