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A 50-year-old may respond more dramatically to CJC-1295/Ipamorelin than a 25-year-old because the baseline is lower

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They concluded that the risk-edited cells increased a T cell activation profile following non-specific TCR engagement, which mimicked the observations exhibited by PTPN22 knockout cells, suggesting the risk variant acts as a loss-of-function mutant that reduces the ability of LYP to inhibit TCR activation (74)

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