In contrast, GLP-1 receptor agonists approved by the FDAincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound, which also activates GIP receptors)are modified to resist DPP-4 degradation
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Thus, the most accurate interpretation is not safe, but rather no stable teratogenic signal identified to date, with evidence still insufficient for a safety conclusion (132). In clinical counseling, this distinction matters: inadvertent early exposure should generally prompt individualized risk communication and obstetric follow-up, not automatic reassurance and not automatic inference of major harm
PMID: 29051322
Symptomatic treatment of neuropathic pain