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They can have side effects, and the dosage needs to be carefully managed and titrated (increased gradually) to ensure both effectiveness and safety

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Specific biophysical mechanisms govern whether a given peptide molecule crosses the sublingual membrane, how quickly it does so, and how much actually reaches the bloodstream intact

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Current pharmacological treatments, and newest clinical developments, are largely based on hormonal manipulation. These are fraught with side effects and are limited to possibly providing pain relief but cannot cure the disease, noted