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362 In AD, elevated ATF6 and XBP1 levels are observed in the hippocampus, where tau tangles and amyloid-\u03b2 plaques accumulate

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HDACis are in early stage clinical trials for Niemann-Pick type C1 (NCT02124083 i ), Alzheimers (NCT03056495 i ), epilepsy (NCT03894826 i ), and Crohns disease (NCT03167437 i ) [90], with Depakene (valproic acid) being used as a first-line therapy for migraine prophylaxis and found to be well-tolerated [91,92]

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