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The researchers calculated each patients 10-year atherosclerotic cardiovascular disease (ASCVD) risk using a tool created by the American College of Cardiology

n = 27100) using metformin doses of 15001700 mg/day reported similar metabolic improvements, including improved lipid profile, insulin sensitivity, blood pressure, and testosterone compared with placebo, while AMH and adiponectin remained unchanged

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Some studies suggest that GLP-1 receptor agonists may have a mild antihypertensive effect, while others have not found a significant impact on blood pressure.However, for patients with pre-existing hypertension, it is still necessary to closely monitor blood pressure changes when using GLP-1 to avoid excessive blood pressure fluctuations that may cause cardiovascular events

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