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Conversely, LPS disrupts the BBB by directly damaging endothelial cells, activating TLR4 to trigger NF-B expression and systemic inflammation, which increases tight junction permeability, induces pericyte degeneration and endothelial apoptosis, and promotes astrocyte foot process phagocytosis (Zhao and Lukiw, 2018

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Innovations such as nanoparticle carriers, liposomes, cyclodextrin complexes, and mucosal delivery methods show promise in preclinical studies

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Use of recombinant human stromal cell-derived factor 1-loaded fibrin/hyaluronic acid hydrogel networks to achieve functional repair of full-thickness bovine articular cartilage via homing of chondrogenic progenitor cells