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Packer L, Witt EH, Tritschler HJ

Recently, ATG43 is identified as another mitophagy-specific receptor, which is localized on the mitochondrial outer membrane and binds to ATG8 ( In mammals, the regulation of mitophagy appears to be more complex, both ubiquitin-mediated and receptor-mediated pathways have been described in response to mitophagy

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IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]

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10.15252/embj.201696151 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang Z.Z., Lee E.E., Sudderth J., Yue Y., Zia A., Glass D., Deberardinis R.J., and Wang R.C