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The analysis of B12 in foods is a challenging task due to low concentrations of natural vitamers in non-supplemented foods, chemical instability of cobalamins, and potential presence of a wide range of structural analogs in the matrices [6, 7]

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In contrast, excessive formation of ROS is responsible for disrupted redox homeostasis which in turn leads to oxidative stress and ROS-mediated damage to all important biomolecules including DNA, proteins, and membranes (Liguori et al