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Endocrinologists : Many focus on diabetes and dont want to manage the behavioral aspects of obesity

GLP-1RAs and osteoclasts The greater degree of bone degradation observed in mice lacking GLP-1R indicates that GLP-1R signaling suppresses osteoclast differentiation and bone resorption

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This dual approach helps patients experience fewer cravings, feel full longer, and achieve better control over their eating habits, all of which contribute to significant weight loss

But the magnitude of natural GLP-1 release is far smaller and shorter-lasting than what prescription agonists achieve