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doi:10.1001/jama.2023.24945 Singh S, Chang HY, Richards TM, Weiner JP, Clark JM, Segal JB

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But the mechanism isnt just more appetite suppression . Theres evidence that GIP signaling may help shift how nutrients are partitioned, potentially favoring fat energy utilization during the fasted state, and possibly mitigating some of the lean mass loss seen with GLP-1 monotherapy

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Moreover, reports are inconsistent, indicating that BMIs, fasting insulin, and free testosterone levels decreased in some meta-analyses, but in other studies, there were no substantial changes in BMI or insulin resistance