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Eating smaller, lower-fat meals and avoiding lying down immediately after eating can help manage nausea during the early weeks of treatment

Panel B, mean (95% confidence interval) change from baseline over time in diastolic blood pressure from start of intensive-lifestyle intervention lead-in period (week -12) to 72 weeks using observed means

Rotating injection sites helps to minimise local irritation

Coaching includes a registered dietitian, fitness coaching, regular MD check-ins, the Points-based food system, and digital community

Give each specific spot at least 4-6 weeks before reusing it

Evening timing also means any injection site tenderness resolves during sleep