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1,25(OH)D facilitates the transcriptional activation of MKP5 by promoting the binding of the VDR/RXR heterodimer to the VDRE within the MKP5 promoter region [205].Building on this, 1,25(OH)D not only regulates downstream MAPK cascades via MKP5 upregulation but also interacts with transcription factors such as NF-B, NFAT, and the glucocorticoid receptor (GCR) through its VDR/RXR complex, orchestrating a multi-level anti-inflammatory response
An important epigenetic process is methylation the addition of a methyl group to a gene, or nearby protein, so that it can no longer be read
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Originally developed to address Type 2 diabetes, it has emerged as a transformative force in the field of weight loss
Keske MA, Clerk LH, Price WJ, Jahn LA, Barrett EJ