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In one component of the study, n=65 patients and n=49 controls were evaluated, but the findings did not establish a clear causal role for DSIP in stress regulation or deep sleep physiology [10]

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Taken daily or weekly, GLP-1RAs replicate the effect of the body's own GLP-1 hormones by binding to specific receptors in the brain and triggering insulin secretion in the pancreas

Key highlights: TRIUMPH-2 (Adults with obesity/overweight + Type 2 Diabetes) * Up to 20.8% mean weight loss (49.6 lbs / 22.5 kg) at 80 weeks

Genetic variants acting as proxies for GLP-1RAs show the lifelong effects of changes in HbA1c levels and GLP-1R gene expression on SA risk, and this impact may not be comparable to the short-term effects of glucose-lowering drugs