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Engineered ECL1 linker residues are shown as dashed circles

In addition to weight loss benefits, GLP-1 therapy is an effective treatment for type 2 diabetes

Table 12: Results at Week 24 (LOCF*) in an Active-Controlled Trial of Dapagliflozin Initial Combination Therapy with Metformin HCl Extended-Release in Adults with Type 2 Diabetes Mellitus Dapagliflozin Add-On To Metformin HCl Immediate-Release A total of 546 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA1c 7% and 10%) participated in a 24-week, placebo-controlled trial to evaluate dapagliflozin in combination with metformin HCl (NCT00528879)

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals

This included Novartis and Probiodrug, a small, privately held German company