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In advanced atherosclerosis stages, prostaglandin endoperoxide synthase 2 (PTGS2), ACSL4, caspase-1, and NOD-like receptor protein 3 (NLRP3) expression is upregulated, while GPX4 is downregulated

However, the researchers did a sensitivity analysis of a 50 mg version and found that it was not as effective as tirzepatide in non-diabetic patients looking to lose weight

[DOI] [PubMed] [Google Scholar] 15.Russell MJ, Hall AJ

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All providers are aware that metformin will lead to a small amount of weight loss, but metformin isnt a weight loss drug