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Semaglutide for the treatment of cognitive dysfunction in major depressive disorder: A randomized clinical trial

[9] In the stomach, somatostatin acts directly on the acid-producing parietal cells via a G-protein coupled receptor (which inhibits adenylate cyclase, thus effectively antagonising the stimulatory effect of histamine) to reduce acid secretion

Generally well tolerated in typical research-style protocols, with most reports noting mild or manageable effects when they occur

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These inconsistencies pose challenges in comparing studies, establishing definitive doseresponse relationships, and extrapolating results from rigorously characterized preparations used in clinical trials to the heterogeneous products accessible to consumers (569)