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Materials and methods Animals and experimental groups Forty adult male Wister albino rats of local strain, weighing 150 20g were purchased from the national research center animal house (Cairo, Egypt)

Clostridium butyricum produces the postbiotic butyrate which stimulates GLP-1. Bifidobacterium infanti

Approval (2017) Once-Weekly Semaglutide in Adults With Overweight or Obesity (March 2021) Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation (June 25, 2021) Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (November 11, 2023) Ozempic Side Effects Two-Year Effects Of Semaglutide In Adults With Overweight Or Obesity: The STEP 5 Trial (October 10, 2022) The Pathophysiology Of Chronic Constipation (October 2011) Dietary Guidelines for Americans, 2020-2025

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