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Adrian Soto-Mota, a physician-scientist who studies metabolic disease, told The Epoch Times in an email

In addition to ghrelin losing its feeding effect in CB1 / animals, neuropeptide Y (NPY) has also been shown to lose its feeding effect in CB1 / animals (Poncelet et al., 2003)

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From this point, your prescriber may continue increasing to 1.7 mg or 2.4 mg weekly, depending on your weight loss progress and how well you tolerate the medication

Increasing daily water intake supports cardiovascular stability during caloric restriction, as dehydration amplifies heart rate elevation and dizziness

The overall cardiometabolic benefit of GLP-1RA rapidly expanded beyond the T2DM population, with the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial describing MACE reduction in the population with overweight and obesity, even in the absence of T2DM [14]