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Dysbiosis-induced disruption of the intestinal barrier aggravates DKD by activating inflammatory responses and reducing SCFA levels ( Figure 2 and Figure 4 ) [126]

The detailed methodological framework is presented in Figure 1

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GLP-1 receptor agonists do not affect sodium intake: Exploratory analyses from two randomized clinical trials

The muscle loss concern, while often overstated, remains clinically relevant for older or frail patientsresearch shows GLP-1-induced weight loss does not cause disproportionate muscle loss in middle-aged adults, but resistance training and adequate protein intake remain essential recommendations