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Older adults People over 65 generally tolerate GLP-1 medications well, but the transition period carries higher risk for dehydration, hypotension, and falls related to GI side effects
Metformin may be continued or initiated as an adjunct or alternative in some cases, in line with NICE guidance
They peak during the first one to two weeks after each dose increase and then gradually subside as the body adjusts
Enhancement of the myelin content and modulation in NO production via influencing the NOS genes in the PFC may be the mechanisms responsible for ALC's beneficial neuroprotective effects
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