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Maintaining adequate dietary fat intake during treatment and not losing weight too rapidly may help reduce this risk

This enzyme complex is composed of the E1 component protein encoded by the DHTKD1 (dehydrogenase E1 and transketolase domain containing 1) gene and shares the E2 (dihydrolipoamide S-succinyltransferase: DLST) and E3 (dihydrolipoamide dehydrogenase: DLD) components of the 2-oxoglutarate complex of the TCA cycle (commonly called -ketoglutarate dehydrogenase)

The approach should be individualized based on pain severity, functional impairment, and underlying etiology once serious pathology has been excluded

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They worsen progressively without any improvement trend

As strong evidence for this, in the present study, l-carnitine supplementation significantly ameliorated the lipid deposition caused by the MD-induced carnitine deficiency