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Freezing them destroys their structure

Studied in models involving NNMT activity, NAD+-related biology, and metabolic pathway regulation

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Most notably, it promotes longevity and stress resistance by activating FOXO transcription factors, which in turn increase catalase and SOD activity, thereby strengthening antioxidant defenses (178180)

[1] [2] These combined effects lead to improved glycemic control and significant weight loss in many patients