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Subsequent studies have further revealed multiple physiological roles for GLP-1R, including its key role in glycemic control
Caveolin-1 The principal protein of caveolae is Cav-1, a 22- to 24-kDa integral membrane protein with a hairpin-like conformation ubiquitously expressed in many different tissues, except striated muscle in which Caveolin 3 is highly expressed ( GLP-1 and its Receptor GLP-1 is an incretin hormone derived from the proglucagon gene and secreted by the intestinal L cell in response to food ingestion to maintain glucose homeostasis ( in vitro and in vivo ( Interaction Between GLP-1R and Caveolin-1 The GLP-1R sequence contains a classical caveolin-1 binding motif within the second intracellular loop (247-EGV Y L Y TLLA F SV F -260) (Uniprot) ( Direct interaction with Cav-1 is required for internalization of receptors in caveolae and also for trafficking of GLP-1R ( Caveolin-1 and GLP-1 Signaling The subcellular localization of a receptor is an important mechanism that regulates signaling specificity
Estimation of globular protein secondary structure from circular dichroism
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Edkins in the discovery of gastrin' World Journal of Surgery , 21, 226-34
