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Lee PA, Nordenstrom A, Houk CP, Ahmed SF, Auchus R, Baratz A, Baratz Dalke K, Liao LM, Lin-Su K, Looijenga LH 3rd, et al

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In a rat model of neuropathic pain induced by tight ligation of L5/L6 spinal nerves, morroniside, administered either orally or intrathecally, dose-dependently alleviated mechanical allodynia, with comparable maximal efficacy (E max ) and an effective dose 50% (ED 50 ) values of 335 mgkg (oral) and 7.1 g (intrathecal) [73]

These observations are based on animal and in vitro research models

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